CHEM 760/7600 - Asymmetric Synthesis of Amino Acids and Total Synthesis of Complex Peptide-Based Natural Products
Semester: Spring 2020Professor: S. Taylor | Discipline: Organic | Campus: Waterloo
Topics covered: peptides as drugs, asymmetric synthesis of common and uncommon amino acids; solution phase, solid phase, and liquid phase peptide synthesis, total synthesis of complex peptide-based natural products such as pipecolidepsin A, yaku’amide A, vioprolide, phomopsin, cyclomarin, bottromycin, lacticin 3147 etc.; and total synthesis of proteins via native chemical ligation.
Final exam: 50 %
Term paper: 25 %
Oral presentation: 25 %