CHEM 760/7600 - Asymmetric Synthesis of Amino Acids and Total Synthesis of Complex Peptide-Based Natural Products

Semester: Spring 2020

Professor: S. Taylor | Discipline: Organic | Campus: Waterloo

Description

Topics covered: peptides as drugs, asymmetric synthesis of common and uncommon amino acids; solution phase, solid phase, and liquid phase peptide synthesis, total synthesis of complex peptide-based natural products such as pipecolidepsin A, yaku’amide A, vioprolide, phomopsin, cyclomarin, bottromycin, lacticin 3147 etc.; and total synthesis of proteins via native chemical ligation.

Materials

TBA

Evaluation

Final exam: 50 %

Term paper: 25 %

Oral presentation: 25 %

Lab/Project

TBA

Schedule

Office Hours

TBA