CHEM 720/7200-02 - Introduction of Experimental Design and Chemometrics

Description

Experimentation is one of the foundational pillars of science. Any theoretical hypothesis that is formulated must ultimately be proved or disproved by experiments. While the scientific method is generally intuitively understood by researchers, not all of them fully realize how various controllable and uncontrollable factors might affect their results. Also, the approach to experimentation is often far from optimal. The course will try to fill these voids by exploring the areas mentioned above. The following topics will be covered:

• Probability, parameters and statistics
• Precision and accuracy
• Evaluation of sources of variation in data (analysis of variance)
• Calibration
• Reliability and drift
• Sensitivity and limit of detection
• Experimental design
  • The origins of experimental design
  • Factorial designs
  • Fractional factorial designs
  • Composite designs
  • Box-Behnken designs
  • Mixture designs
  • Placket-Burman design
• Least squares
• Multivariate approaches
• Optimization of analytical methods