CHEM 766/7660 - Organic Spectroscopy
Semester: Fall 2020Professor: J.M. Chong | Discipline: Organic | Campus: Waterloo
This course will deal with aspects of organic spectroscopy from the perspective of an organic chemist. There will be an emphasis on fundamental principles relevant to different spectroscopic techniques but with a minimum of quantum mechanics and mathematics. Applications of spectroscopic methods to the elucidation of organic structures will be stressed.
Some basic organic chemistry knowledge (e.g. usually 4 bonds to a neutral carbon atom, common functional groups) will be assumed but in-depth knowledge of new synthetic methods or reaction mechanisms is neither expected nor required.
There will be no official course textbook. Textbooks such as Silverstein’s “Spectrometric Identification of Organic Compounds” or Lambert’s “Organic Structural Spectroscopy” will be useful guides.
- Assignments (4) 50
- Final exam 50
Nuclear Magnetic Resonance Spectroscopy (8 weeks)
- 1H NMR spectroscopy: Basic principles, instrumentation, factors affecting chemical shifts, equivalence of nuclei, spin-spin coupling, second order spectra, relaxation…
- 13C NMR spectroscopy
- Multiple pulse techniques: COSY, HMQC, HMBC, NOESY, …
- Exchange phenomena and dynamic NMR
- Other nuclei (e.g. 2H, 15N, 19F, 31P)
Vibrational spectroscopy (1 week)
- Theory of infrared absorption and Raman scattering, instrumentation
- Group frequencies and structure determination
Mass spectrometry (3 weeks)
- Theory, instrumentation, ionization methods
- Structure determination: use of M+, isotopes and fragmentation patterns
- Thu: 7:00 pm - 9:20 pm in EIT 2053/MacN 101