CHEM 766/7660 - Organic Spectroscopy

Semester: Fall 2018

Professor: J.M. Chong | Discipline: Organic | Campus: Waterloo

Description

This course will deal with aspects of organic spectroscopy from the perspective of an organic chemist.  There will be an emphasis on fundamental principles relevant to different spectroscopic techniques but with a minimum of quantum mechanics and mathematics.  Applications of spectroscopic methods to the elucidation of organic structures will be stressed.

Some basic organic chemistry knowledge (e.g. usually 4 bonds to a neutral carbon atom, common functional groups) will be assumed but in-depth knowledge of new synthetic methods or reaction mechanisms is neither expected nor required.

Materials

There will be no official course textbook.  Textbooks such as Silverstein’s “Spectrometric Identification of Organic Compounds” or Lambert’s “Organic Structural Spectroscopy” will be useful guides.

Evaluation

  • Assignments (4)          50
  • Final exam                  50

Lab/Project

Nuclear Magnetic Resonance Spectroscopy (8 weeks)

  • 1H NMR spectroscopy: Basic principles, instrumentation, factors affecting chemical shifts, equivalence of nuclei, spin-spin coupling, second order spectra, relaxation…
  • 13C NMR spectroscopy
  • Multiple pulse techniques: COSY, HMQC, HMBC, NOESY, …
  • Exchange phenomena and dynamic NMR
  • Other nuclei (e.g. 2H, 15N, 19F, 31P)

Vibrational spectroscopy (1 week)

  • Theory of infrared absorption and Raman scattering, instrumentation
  • Group frequencies and structure determination

Mass spectrometry (3 weeks)

  • Theory, instrumentation, ionization methods
  • Structure determination: use of M+, isotopes and fragmentation patterns

Schedule

  • Wed: 7:00 pm - 9:20 pm in C2 278/MacN 203

Office Hours

Office: C2-364, Department of Chemistry, University of Waterloo Phone: 519-888-4567 x36643 (office), 519-888-4581 (lab: C2-363) E-mail: [email protected]